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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS2
All Species:
15.15
Human Site:
S683
Identified Species:
25.64
UniProt:
P54840
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54840
NP_068776.2
703
80989
S683
R
D
R
L
N
I
K
S
P
F
S
L
S
H
V
Chimpanzee
Pan troglodytes
XP_520790
703
80912
S683
R
D
R
L
N
I
K
S
P
F
S
L
S
H
V
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
K683
D
E
D
E
E
A
A
K
D
R
R
N
I
R
A
Dog
Lupus familis
XP_534869
703
80957
S683
R
D
R
L
N
I
K
S
P
F
S
L
G
R
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCB3
704
80866
K683
E
R
D
R
L
N
I
K
S
P
F
S
L
N
H
Rat
Rattus norvegicus
P17625
704
80715
K683
E
R
D
R
L
N
I
K
S
P
F
S
L
N
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
I683
A
E
K
D
R
R
N
I
R
A
L
E
W
Q
R
Chicken
Gallus gallus
XP_416432
704
81032
S684
R
D
R
Q
N
I
K
S
P
F
S
L
G
V
L
Frog
Xenopus laevis
NP_001084863
702
80811
S682
R
D
R
Q
N
I
K
S
T
F
S
F
G
P
V
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
Q681
K
D
R
V
N
I
R
Q
P
Y
N
L
P
N
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
G690
T
P
A
P
S
V
H
G
S
D
D
E
D
S
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
N648
V
D
K
I
M
R
D
N
E
G
K
V
P
S
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
D682
Q
D
A
N
N
A
D
D
Y
F
N
L
S
T
N
Red Bread Mold
Neurospora crassa
O93869
706
80888
E673
A
W
K
L
P
E
E
E
D
P
E
E
Y
P
F
Conservation
Percent
Protein Identity:
100
99.7
68.1
95.7
N.A.
94
93.3
N.A.
68
84.2
80.6
71.4
N.A.
56.9
N.A.
50.9
N.A.
Protein Similarity:
100
100
81.8
98.5
N.A.
96.5
96.3
N.A.
81.5
92.1
91.4
85.9
N.A.
73.9
N.A.
67.1
N.A.
P-Site Identity:
100
100
0
86.6
N.A.
0
0
N.A.
0
73.3
66.6
40
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
6.6
86.6
N.A.
6.6
6.6
N.A.
13.3
80
66.6
80
N.A.
20
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49
50.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
66.8
67.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
15
0
0
15
8
0
0
8
0
0
0
0
15
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
58
22
8
0
0
15
8
15
8
8
0
8
0
0
% D
% Glu:
15
15
0
8
8
8
8
8
8
0
8
22
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
43
15
8
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
8
0
8
0
0
22
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
15
15
% H
% Ile:
0
0
0
8
0
43
15
8
0
0
0
0
8
0
0
% I
% Lys:
8
0
22
0
0
0
36
22
0
0
8
0
0
0
0
% K
% Leu:
0
0
0
29
15
0
0
0
0
0
8
43
15
0
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
50
15
8
8
0
0
15
8
0
22
8
% N
% Pro:
0
8
0
8
8
0
0
0
36
22
0
0
15
15
0
% P
% Gln:
8
0
0
15
0
0
0
8
0
0
0
0
0
8
0
% Q
% Arg:
36
15
43
15
8
15
8
0
8
8
8
0
0
15
15
% R
% Ser:
0
0
0
0
8
0
0
36
22
0
36
15
22
15
0
% S
% Thr:
8
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% T
% Val:
8
0
0
8
0
8
0
0
0
0
0
8
0
8
36
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _